LUNG STAGING IN PEDIATRIC HODGKIN LYMPHOMA: STAGING EVALUATION & RESPONSE CRITERIA HARMONIZATION FOR CHILDHOOD, ADOLESCENT & YOUNG ADULT HL (SEARCH FOR CAYAHL) CONSENSUS

Introduction: Staging of lung lesions in pediatric Hodgkin lymphoma (HL) is a long standing, controversial issue. Consortium groups define involvement and its distinction from E-lesions differently. Application these criteria to individual patients are technically challenging require expertise. The SEARCH group, working create harmonization across consortia for the staging HL, has completed this task lesions. Methods: A survey 7 case vignettes was distributed 26 world experts replicating previously published by Connors et al 1984. Experts were asked stage each as involvement, or an E-lesion. Similar findings, our results demonstrated that greatly divided on several cases, indicating ongoing differences interpretation. Accordingly, group performed initiative contemporary Representatives major consortium (Pediatric Consortium, EuroNet PHL, Children’s Oncology Group) provided their current definitions rationale decisions cases presented. Based discussions, Delphi drafted containing 12 statements pertaining electronically members committee representing consortium. Consensus defined score 3.75 greater 5-point Likert scale (strongly disagree [1] strongly agree [5]). rounds continued until consensus achieved all statements, decision made remove statement. Responses collected anonymously scores pooled reviewed after round. Extreme comments calls before proceeding next Results: 21 responded first round, including oncologists, nuclear medicine radiologists, radiation oncologists. 8 met Round 1. Several edited improve clarity 1 statement added. second round with 20 responses. All exception one which ultimately removed further investigation required. Final available Figure Keywords: lymphoma, non-Hodgkin (pediatric, adolescent, young adult) No conflicts interests pertinent abstract.